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╒ age Age of patient cAsymp 7 Cost of a single year in the asymptomatic disease state ■ cDeath Cost associated with a death cDR Discount rate applied to costs cDrug " Cost of the drug therapy per cycle Ь0В cProg 2 Cost of one cycle in the progressive disease state \лS eff * Drug effectiveness at reducing progression АлS ini_age oDR ! Discount rate applied to outcomes tpDcm @ Co-morbid death: risk of death from progressive stage of disease ┤lБ tpProg F Coefficient of increase for transition to progressive phase of disease Coef uAsymp - Utility weight for asymptomatic disease state uProg , Utility weight for progressive disease state ╒ ╒ QALYs ╩ Times New Roman ╩ Times New Roman b ╩ Times New Roman ╩ Times New Roman ╩ Times New Roman {^} ╩ Times New Roman ╚ ╒ ╒ ╒ Drug intervention?
╒ age ini_age+_stage cAsymp 500. cDeath 1000. cDR 0.035 cDrug 1000. cProg 3000. eff 0.5 ini_age 55. oDR 0.035 tpDcm 0.15 tpProg 0.01 uAsymp 0.95 uProg 0.75 No drug therapy arm _stage>45 _stage>45 _stage=45 Asymptomatic disease 1 ! 0.5 * ( cAsymp/((1+cDR)^_stage) ) cAsymp/((1+cDR)^_stage) ! 0.5 * ( cAsymp/((1+cDR)^_stage) ) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) uAsymp/((1+oDR)^_stage) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) 0.5 * ( 1/((1+oDR)^_stage) ) 1/((1+oDR)^_stage) 0.5 * ( 1/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Progressive disease tpProg*(_stage+1) Progressive disease Dead (other causes)
natDeath[age] Dead (other causes) Asymptomatic disease # Asymptomatic disease Progressive disease 0 0.5 * ( cProg/((1+cDR)^_stage) ) cProg/((1+cDR)^_stage) 0.5 * ( cProg/((1+cDR)^_stage) ) 0.5 * ( uProg/((1+oDR)^_stage) ) uProg/((1+oDR)^_stage) 0.5 * ( uProg/((1+oDR)^_stage) ) 0.5 * ( 1/((1+oDR)^_stage) ) 1/((1+oDR)^_stage) 0.5 * ( 1/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead (other causes)
natDeath[age] Dead (other causes) Progressive disease # Progressive disease Dead from disease tpDcm Dead from disease cDeath/((1+cDR)^_stage) Dead (other causes) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead from disease 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Drug therapy arm _stage>45 _stage>45 _stage=45 Asymptomatic disease 1 ) 0.5 * ( (cAsymp+cDrug)/((1+cDR)^_stage) ) (cAsymp+cDrug)/((1+cDR)^_stage) ) 0.5 * ( (cAsymp+cDrug)/((1+cDR)^_stage) ) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) uAsymp/((1+oDR)^_stage) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) 0.5 * ( 1/((1+oDR)^_stage) ) 1/((1+oDR)^_stage) 0.5 * ( 1/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Progressive disease tpProg*(_stage+1)*eff Progressive disease Dead (other causes)
natDeath[age] Dead (other causes) Asymptomatic disease # Asymptomatic disease Progressive disease 0 0.5 * ( cProg/((1+cDR)^_stage) ) cProg/((1+cDR)^_stage) 0.5 * ( cProg/((1+cDR)^_stage) ) 0.5 * ( uProg/((1+oDR)^_stage) ) uProg/((1+oDR)^_stage) 0.5 * ( uProg/((1+oDR)^_stage) ) 0.5 * ( 1/((1+oDR)^_stage) ) 1/((1+oDR)^_stage) 0.5 * ( 1/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead (other causes)
natDeath[age] Dead (other causes) Progressive disease # Progressive disease Dead from disease tpDcm Dead from disease cDeath/((1+cDR)^_stage) Dead (other causes) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead from disease 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ╒ ╒ ╒ Ё? ╒ 0 20000 0.1 10 ш d ╒ ╒ ` ╚ ┴ d ( ┴ ╚ ( ┴ * Ї К X ┴ V ┬ X аЖ Р & & █ d
P K ╖D ╖ natDeath ╖ ╖ ╒ АK@ lxzе,CМ? @P@ ║k ∙аgг? └R@ ╘+eтX╖? @U@ 9EGr∙╔? ╖ Value P P