gE 1 1 " T< c_Asymp Dist(2) c_Death Dist(1) c_Drug Dist(4) c_Prog Dist(3) Eff_D Dist(7) tp_Dcm Dist(8) tp_Prog Dist(10) u_Asymp Dist(5) u_Prog Dist(6)
age Age of patient cAsymp @o@ 250 p@ 750 7 Cost of a single year in the asymptomatic disease state cDeath @@ 500 p@ 1500 Cost associated with a death cDR 0 Q? .06 Discount rate applied to costs cDrug @ 800 @ 1200 " Cost of the drug therapy per cycle 0 cProg @@ 2000 @@ 4000 2 Cost of one cycle in the progressive disease state \S eff ? 0.4 333333? 0.6 * Drug effectiveness at reducing progression S ini_age oDR 0. Q? 0.06 ! Discount rate applied to outcomes tpDcm ? 0.1 ? 0.2 @ Co-morbid death: risk of death from progressive stage of disease l tpProg {Gzt? 0.005 Q? 0.015 F Coefficient of increase for transition to progressive phase of disease Coef uAsymp ? 0.9 ? 1.0 - Utility weight for asymptomatic disease state uProg 333333? 0.6 ? 0.9 , Utility weight for progressive disease state QALYs Times New Roman Times New Roman d Times New Roman Times New Roman Times New Roman {^} Times New Roman Drug intervention?
age ini_age+_stage cAsymp c_Asymp cDeath c_Death cDR 0.035 cDrug c_Drug cProg c_Prog eff Eff_D ini_age 55. oDR 0.035 tpDcm tp_Dcm tpProg tp_Prog uAsymp u_Asymp uProg u_Prog No drug therapy arm _stage>45 _stage>45 _stage=45 Asymptomatic disease 1 ! 0.5 * ( cAsymp/((1+cDR)^_stage) ) cAsymp/((1+cDR)^_stage) ! 0.5 * ( cAsymp/((1+cDR)^_stage) ) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) uAsymp/((1+oDR)^_stage) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Progressive disease tpProg*(_stage+1) Progressive disease Dead (other causes)
natDeath[age] Dead (other causes) Asymptomatic disease # Asymptomatic disease Progressive disease 0 0.5 * ( cProg/((1+cDR)^_stage) ) cProg/((1+cDR)^_stage) 0.5 * ( cProg/((1+cDR)^_stage) ) 0.5 * ( uProg/((1+oDR)^_stage) ) uProg/((1+oDR)^_stage) 0.5 * ( uProg/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead (other causes)
natDeath[age] Dead (other causes) Progressive disease # Progressive disease Dead from disease tpDcm Dead from disease cDeath/((1+cDR)^_stage) Dead (other causes) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead from disease 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Drug therapy arm _stage>45 _stage>45 _stage=45 Asymptomatic disease 1 ) 0.5 * ( (cAsymp+cDrug)/((1+cDR)^_stage) ) (cAsymp+cDrug)/((1+cDR)^_stage) ) 0.5 * ( (cAsymp+cDrug)/((1+cDR)^_stage) ) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) uAsymp/((1+oDR)^_stage) ! 0.5 * ( uAsymp/((1+oDR)^_stage) ) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Progressive disease tpProg*(_stage+1)*eff Progressive disease Dead (other causes)
natDeath[age] Dead (other causes) Asymptomatic disease # Asymptomatic disease Progressive disease 0 0.5 * ( cProg/((1+cDR)^_stage) ) cProg/((1+cDR)^_stage) 0.5 * ( cProg/((1+cDR)^_stage) ) 0 uProg/((1+oDR)^_stage) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead (other causes)
natDeath[age] Dead (other causes) Progressive disease # Progressive disease Dead from disease tpDcm Dead from disease cDeath/((1+cDR)^_stage) Dead (other causes) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Dead from disease 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 c_Death 15.3664 0.015366 c_Asymp 15.3664 0.030733 c_Prog 34.5744 0.011525 c_Drug 96.04 0.09604 u_Asymp 68.39088 3.59952 u_Prog 23.26 7.75333 Eff_D
-0.6931472 0.0930212 tp_Dcm 29.23824 165.23824
tp_Prog
-4.6051702 0.20687 ? 0 20000 0.1 10 cAsymp ` d ( ( * X X & & d
P K D natDeath K@ lxz,C? @P@ k g? R@ +eX? @U@ 9EGr? Value P P