Coronary artery grafting in high risk patients. A randomised trial of off-pump versus on-pump surgery (the CRISP Trial)
|Funding:||Medical Research Council; British Heart Foundation|
|Collaborators:||Nuffield Department of Surgery, University of Oxford; Bristol Heart Institute|
This is a randomized controlled trial designed to compare the effectiveness and cost-effectiveness of performing coronary artery bypass grafting (CABG) without cardiopulmonary bypass (off pump) against conventional CABG in which cardiopulmonary bypass (on pump) is used to support circulation whilst the heart is temporarily stopped. The economic evaluation to be conducted by HERC has been designed as an integral part of the trial.
Resource use data relating to the initial procedures, hospital inpatient stay, medication use and follow-up to 12 months will be collected from trial patients and costed. Patients will also complete the EuroQol EQ-5D at various time points out to 12 months.
In addition to a within trial analysis, health economic modelling will also be used to extrapolate life time costs, survival and QALYs with each intervention. Incremental analyses are planned in which results will be expressed as a cost per life year gained and a cost per QALY gained.