Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Dates: 2004-2009
Funding: NIHR Health Technology Assessment programme (HTA)
Collaborators: Dr Stavros Petrou, University of Warwick. Dr. Ian Williamson and Dr. Sarah Benge, University of Southampton
Information: Helen Dakin

Otitis media with effusion is a common condition in childhood, and in its chronic and recurrent forms a source of substantial NHS costs, with over £200 million per year spent on related prescribing. The majority of children are referred on from primary care, but confusions over treatment and uncertain diagnosis have historically contributed to a broad and at times inequitable gateway to secondary services.  GNOME is a randomised controlled placebo-controlled trial evaluating topical intra-nasal steroids in 4-11 year old children with persistent bilateral otitis media with effusion, in primary care. HERC estimated the cost-effectiveness of the treatment over the nine month follow-up period of the trial. The application of multi-attribute utility measures within the trial has also allowed us to address important methodological issues around utility measurement in childhood, such as mapping between the disease-specific OM8-30 questionnaire and multi-attribute utility measures.

The results of the GNOME study have been published as a Health Technology Assessment report. In addition, the results of the economic evaluation have been published in Value in Health, clinical results have been published in the British Medical Journal and a separate study that maps between the OM8-30 health related quality of life measure and HUI has been published in Quality of Life Research.

Publications

Petrou S, Dakin H, Abangma G, Benge S, Williamson, I (2010). Cost-utility analysis of topical intranasal steroids for otitis media with effusion based on evidence from the GNOME trial. Value Health, 13, 543 - 551

Dakin, H, Petrou, S, Haggard, M, Benge, S, and Williamson, I (2010). Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. Qual Life Res, 19(1):65-80.

Williamson, I, Benge, S, Barton, S, Petrou, S, Letley, L, Fasey, N, Haggard, M, and Little, P. 2009. Topical intranasal corticosteroids in 4-11 year old children with persistent bilateral otitis media with effusion in primary care: a double blind randomised placebo controlled trial. British Medical Journal; 339:b4984, doi: 10.1136/bmj.b4984

Williamson, I, Benge, S, Petrou, S, Letley, L, Fasey, N, Abangma, G, Dakin, H, and Little, P. 2009. A double-blind randomised placebo controlled trial of topical intra-nasal corticosteroids in 4-11 year old children with persistent bilateral Otitis Media with Effusion in primary care Health Technology Assessment. 13(37):1-144.