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Approximately £400 million is spent on consultations and lost productivity associated with sore throat in the UK annually. The TOAST trial is a double-blind, randomised, placebo-controlled trial in adults presenting to primary care with acute sore throat. The intervention is a single dose of oral dexamethasone (10mg), compared to placebo, in the treatment of sore throat.

Time scale 2013-2015
Funder NIHR School for Primary Care Research Project
PI Dr. Gail Hayward
In collaboration with University of Oxford, University of Bristol, University of Southampton, University of Washington
Further information Jane Wolstenholme and Richéal Burns

Research Objectives:

This trial aims to assess the efficacy and cost-effectiveness of a single oral dose of corticosteroids on symptoms of sore throat in patients receiving either a delayed antibiotic prescription or no antibiotics at all in UK primary care.

Research Outputs:

Oral corticosteroid use for clinical and cost-effective symptom relief of sore throat: study protocol for a randomized controlled trial. Cook J., Hayward G., Thompson M., Hay AD., Moore M., Little P., Harman K., Wolstenholme J., Perera R., Voysey M., Allen J., Breen M., Heneghan C. Trials 2014; 15: 365