FACS : Follow-up After Colorectal Surgery
|Dates:||ongoing since 2002|
|Funding:||Department of Health, Research and Development Programme|
|Collaborators:||University Surgical Unit, University of Southampton|
This is a randomised controlled trial of patients who have undergone resection for colorectal cancer with curative intent. The trial will assess the effect on the number of surgically treatable recurrences of augmenting routine follow-up in primary care with three more intensive methods of follow-up: monitoring of CEA (carcino embryonic antigen) in primary care, hospital-based imaging, and hospital-based imaging plus CEA monitoring in primary care. Target recruitment for the trial was 1200 patients and was reached in October 2009.
Health economic data on resource use and quality of life are being collected from patients in the trial and will be combined with published data on survival following recurrence in order to generate estimates of the lifetime costs and quality adjusted life years (QALYs) associated with each of the follow-up regimes. Incremental analyses will be performed and the results expressed in terms of an incremental cost per QALY gained.
Primrose, JN, Perera, R, Gray, A, Rose, P, Fuller, A, Corkhill, A, George, S, and Mant, D (2014). Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial. JAMA, 311(3):263-70.