Sarah joined HERC in September 2018 to complete her DPhil under the supervision of Sarah Wordsworth. She is developing a genetic and environmental risk model for colorectal cancer, and evaluating the clinical utility and cost effectiveness of using this model to stratify approaches to bowel cancer screening in the English Bowel Cancer Screening Programme by prior risk. She is using UK Biobank (genetic, epidemiological and hospital data) to develop her risk model, and a HERC model of bowel cancer screening (Murphy et al. 2017) to evaluate its impact.
Sarah graduated with BMBCh from the University of Oxford. She then undertook an Academic Foundation post at Kings College Hospital, London, followed by an Academic Clinical Fellowship in Medical Oncology in Oxford, researching inherited predisposition to colorectal cancer under the supervision of Professor Ian Tomlinson (now at the University of Birmingham). She subsequently worked as a Medical Oncology registrar before beginning her DPhil studies.
Development and Assessment of a Genetic and Environmental Risk Model for Colorectal Cancer
Dr Sarah Wordsworth (HERC, Nuffield Department of Population Health)
Dr James East (Experimental Medicine, Nufield Department of Medicine)
Professor Julia Hippisley-Cox (Nuffield Department of Primary Care Health Sciences)
Professor Ian Tomlinson (University of Birmingham)
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law PJ. et al, (2019), Nat Commun, 10
Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Domingo E. et al, (2016), Lancet Gastroenterology and Hepatology
Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Palles C. et al, (2015), Gastroenterology, 148, 367 - 378
Antiangiogenesis: Focus on colorectal cancer
Briggs S. and Midgley R., (2014), Clinical Insights: Antiangiogenesis in Cancer Therapy, 69 - 89
DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.
Church DN. et al, (2013), Hum Mol Genet, 22, 2820 - 2828