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INTRODUCTION: There are a trend towards increasing use of High-Flow Nasal Cannula (HFNC), outside of paediatric intensive care unit. Give this trend is necessary to update the actual evidence and to assess available published literature to determinate the efficacy of HFNC over Continuous Positive Air Pressure (CPAP) as treatment for children with severe bronchiolitis. METHODS: We searched MEDLINE, EMBASE, LILACS, and COCHRANE Central, and gray literature in clinical trials databases ( www. CLINICALTRIALS: gov ), from inception to June 2022. The inclusion criteria for the literature were randomized clinical trials (RCTs) that included children 

Original publication





BMC Pediatr

Publication Date





Bronchiolitis, Children, Continuous positive air pressure, Continuous positive airways pressure, High flow oxygen cannula, High-flow nasal cannula, Severe bronchiolitis, Child, Humans, Child, Preschool, Cannula, Oxygen, Bronchiolitis, Continuous Positive Airway Pressure, Respiration, Artificial, Randomized Controlled Trials as Topic