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BACKGROUND: This article presents a valuation study to estimate a preference-based index for a 5-dimensional health state classification for asthma (AQL-5D) derived from the Asthma Quality of Life Questionnaire (AQLQ). METHODS: A sample of 307 members of the UK general population valued 99 asthma health states selected from the AQL-5D using the time tradeoff technique. Models were estimated to predict all possible 3125 health states defined by the AQL-5D, and the models were compared in terms of their ability to predict mean values for the 99 states. RESULTS: Mean health state values ranged from 0.39 to 0.94 based on an average of 22 valuations per state. A main effects model estimated on mean health state values and adjusted for consistency had the best predictive ability (mean absolute error of 0.047 and only 9/98 states with errors >0.1) and the most logical consistency with levels of the AQL-5D. The low number of valuations per state may have resulted in unreliable estimates for the models. Preference-based condition specific measures are limited in their ability to make cross-disease comparisons. CONCLUSION: This is the first study to derive a condition-specific preference-based measure from an existing measure of health-related quality of life in asthma for use in economic evaluation.

Original publication

DOI

10.1177/0272989X10379646

Type

Journal

Med Decis Making

Publication Date

03/2011

Volume

31

Pages

281 - 291

Keywords

Adolescent, Adult, Aged, Asthma, Female, Health Status, Humans, Male, Middle Aged, Models, Theoretical, Quality of Life, Surveys and Questionnaires, Young Adult