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OBJECTIVES: The aim of the study is to estimate a preference-based single index for calculating quality-adjusted life years for patients with overactive bladder (OAB), based on a survey of the UK general population using the 5-dimensional health classification system OAB-5D, derived from the validated Overactive Bladder Questionnaire (OAB-q). METHODS: An interview valuation survey of members of public in the South Yorkshire, UK was undertaken using the time-trade-off method. Each respondent was randomly allocated to one of 14 blocks, and valued seven states each plus the "pits" state, so that a total of 99 states were valued. A number of multivariate regression models were estimated for predicting a total of 3125 health state values defined by the classification. Models were compared and selected using a set of criteria, including overall diagnosis by adjusted R-squared, the sign and significance of individual parameter estimates, the relative size of coefficients within a given dimension and predictive ability. RESULTS: The mean model was recommended for use in economic evaluation. CONCLUSION: This will permit the cost-effectiveness of new interventions to be assessed in patients with OAB using existing and future OAB-q data sets.

Original publication

DOI

10.1111/j.1524-4733.2008.00413.x

Type

Journal

Value Health

Publication Date

01/2009

Volume

12

Pages

159 - 166

Keywords

Adolescent, Adult, Aged, Female, Health Status, Humans, Interviews as Topic, Male, Middle Aged, Models, Economic, Patient Preference, Quality-Adjusted Life Years, United Kingdom, Urinary Bladder, Overactive, Young Adult