Total or Partial Knee Arthroplasty
|Funding:||NIHR Health Technology Assessment Programme|
|Collaborators:||Dr David Beard, Nuffield Orthopaedic Centre NHS Trust, Oxford|
TOPKAT is a randomised controlled trial designed to compare the effectiveness and cost-effectiveness of total knee replacement (replacing all three compartments of the joint) versus unicompartmental knee replacement (replacing only a single compartment of the joint) in patients with osteoarthritis of the knee. An economic evaluation has been designed as an integral part of the TOPKAT trial and is being conducted by HERC.
Resource use data relating to the initial surgical procedures, hospital inpatient stay, complications and surgical revisions and follow-up to five years will be collected from trial patients and costed. Over the same time period information on health related quality of life will be collected from patients using the EQ-5D questionnaire, and will be combined with survival data to generate quality adjusted life years (QALYs).
A within trial analysis is planned with results expressed as an incremental cost per QALY gained. Health economic modelling will be used to extrapolate costs and QALYS over a lifetime horizon.