Professor Alastair Gray
Professor of Health Economics, HERC
- Health Economics Research Centre
My research focuses on the use of economics to improve resource allocation and decision making in health care. In particular, I am interested in using robust methods to estimate the likely cost-effectiveness of new and existing health care interventions. This may involve synthesising information from different sources on costs, outcomes and effectiveness in a decision-analytic model. But most commonly I work with clinicians and triallists to collect individual patient information within large randomised trials, typically assembling and analysing data on the cost of the intervention and the alternative, the outcomes in terms of quality of life and survival, and the cost-effectiveness in the trial and in routine care.
The economic evaluations I am involved in span many different clinical areas, from psychiatry to neurosurgery and care of the elderly. But I have particular interests in diabetes, orthopaedic surgery and population screening. These studies often involve the development and use of disease models, typically based on individual patient data, to predict lifetime costs and outcomes; my group has developed these in areas such as diabetes, cardiovascular disease, kidney disease and breast cancer.
Quality of life is a crucial aspect of much of my work, and so I am also interested in the methodologies used to measure and value different health states, different conceptions of quality of life, and the association between different quality of life measures.
Finally, I have a long-standing interest in wider economic aspects of health care, including the impact of demographic change and ageing populations on health systems, and the economics of health care errors and adverse events.
Teaching and training are a fundamental aspect of my work, and I typically am supervising 2-4 doctoral students as well as contributing to HERC’s short courses and the MSc Global Health Sciences.
Applied Methods of Cost-Effectiveness Analysis in Healthcare
Gray AM. et al, (2011)
UKPDS Outcomes Model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year United Kingdom Prospective Diabetes Study: UKPDS 82
Hayes AJ. et al, (2013), Diabetologia
Economic evaluation alongside randomised controlled trials: design, conduct, analysis, and reporting
Petrou S. and Gray A., (2011), Bmj-British Medical Journal, 342
Rationing of total knee replacement: a cost-effectiveness analysis on a large trial data set.
Dakin H. et al, (2012), BMJ Open, 2
Cost-effectiveness of bilateral versus single internal thoracic artery grafts at ten years.
GRAY A. et al, (2021), European Heart Journal – Quality of Care and Clinical Outcomes
Health-related quality of life in people with predementia Alzheimer's disease, mild cognitive impairment or dementia measured with preference-based instruments: a systematic literature review.
Landeiro F. et al, (2020), Alzheimers Res Ther, 12
Economic Evaluation of Factorial Trials: Cost-Utility Analysis of the Atorvastatin in Factorial With Omega EE90 Risk Reduction in Diabetes 2 × 2 × 2 Factorial Trial of Atorvastatin, Omega-3 Fish Oil, and Action Planning
Dakin H. et al, (2020), Value in Health
Obtaining EQ-5D-5L utilities from the disease specific Quality of Life Alzheimer’s Disease Scale: Development and results from a mapping study
ROMBACH I. et al, (2020), Quality of Life Research
Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge.
Si L. et al, (2020), Value Health, 23, 1163 - 1170