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Prostate Cancer: Modelling the cost-effectiveness of screening

Dates: 2005-2010
Funding: Cancer Research UK
Collaborators:  Professor Tony Ades, University of Bristol
Information: Jane Wolstenholme, José Leal

The aim of this project was to assess the cost-effectiveness of screening for prostate cancer in the UK using PSA testing. A model has been developed representing a cohort of men in which PSA testing is superimposed on a background of prostate cancer natural history and clinical diagnosis in the absence of screening.  The underlying incidence of histological cancer is an adapted version of that developed by Etzioni and colleagues (1998) under which a Markov model of disease progression was introduced.  Multi-parameter evidence synthesis (MPES) methods were used to synthesise several sources of evidence informing on the prevalence of prostate cancer, natural history and impact of screening. Probabilistic sensitivity analysis were employed to explore the decision uncertainty concerning the cost-effectiveness of screening.

Publications

Leal, J, Hamdy, F, and Wolstenholme, J (2014). Estimating age and ethnic variation in the histological prevalence of prostate cancer to inform the impact of screening policies. Int J Urol, 21(8):786-92.

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