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Mixed treatment comparison meta-analysis of topical treatments for primary open-angle glaucoma and ocular hypertension

Dates: 2008-2011
Funding: Pfizer
Collaborators: Multi-parameter Evidence Synthesis Research Group, University of Bristol
Information: Helen Dakin

Primary open angle glaucoma (POAG) comprises a chronic, irreversible condition in which elevated intraocular pressure (IOP) causes damage to the optic nerve head, leading to visual field defects. There are now a number of topical treatments that lower IOP, although relatively little is known about their relative efficacy. IOP also varies during the course of the day and during the course of treatment, with different trials reporting outcomes at different time points.

This study further developed the techniques of mixed treatment comparison (MTC) meta-analysis to allow for changes in IOP over time. The models developed were used to evaluate the relative efficacy of topical treatments for POAG and ocular hypertension, adjusting for the timing of IOP measurements.

The analysis is now complete and has been published in Statistics in Medicine.


Dakin, HA, Welton, NJ, Ades, AE, Collins, S, Orme, M, and Kelly, S (2011). Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. Stat Med. Published Online July 2011.